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S5B, GLP-1 RA intervention was associated with a reduction in total testosterone levels when compared to those given placebo (MD = 0.22
Why the pairing is plausible The logic for combining them comes from pathway biology: tesamorelin works through the GHRH receptor, while ipamorelin works through the ghrelin/GHS-R1a receptor
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The ACOG Practice Bulletin on hormonal contraception does not list GLP-1 RAs as interacting drugs [12]
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